Why You’ll Love This Recipe
Homemade Southern Chicken Spaghetti is the ultimate comfort food, bringing together tender chicken, creamy sauce, and perfectly cooked spaghetti with a rich Southern twist. Unlike traditional Italian spaghetti, this version is baked in a cheesy, savory sauce made with cream of mushroom soup, cream of chicken soup, and plenty of flavorful seasonings. It’s hearty, filling, and absolutely perfect for feeding a crowd or enjoying as a family meal. Whether served at Sunday supper, church gatherings, or weeknight dinners, this casserole-style dish has all the makings of a Southern classic—simple ingredients, bold flavors, and an irresistible creamy texture. Easy to prepare ahead of time and freezer-friendly, this recipe is both practical and indulgent.
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Homemade Southern Chicken Spaghetti – A Comfort Food Classic
- Total Time: 50 mins
- Yield: 6 servings
- Diet: Halal
Description
A creamy, cheesy Southern classic made with tender chicken, spaghetti, and a flavorful blend of peppers, onions, and seasonings baked to perfection.
Ingredients
- 12 oz spaghetti
- 2 cups cooked chicken breast, shredded
- 2 tbsp olive oil
- 1 small onion, diced
- 1 green bell pepper, diced
- 1 red bell pepper, diced
- 2 cloves garlic, minced
- 1 can (10.5 oz) cream of chicken soup
- 1 can (10.5 oz) cream of mushroom soup
- 1 can (10 oz) diced tomatoes with green chilies
- 1/2 cup chicken broth
- 2 cups shredded cheddar cheese, divided
- 1 tsp paprika
- 1/2 tsp cayenne pepper (optional, for heat)
- Salt and black pepper, to taste
- 2 tbsp fresh parsley, chopped (for garnish)
Instructions
- Preheat oven to 350°F (175°C) and grease a 9×13-inch baking dish.
- Cook spaghetti according to package directions until al dente. Drain and set aside.
- In a skillet, heat olive oil over medium heat. Add onion, bell peppers, and garlic. Cook until softened.
- Stir in cream of chicken soup, cream of mushroom soup, diced tomatoes with chilies, chicken broth, paprika, cayenne (if using), salt, and pepper.
- Add shredded chicken and cooked spaghetti to the sauce mixture, stirring until evenly coated.
- Pour mixture into the prepared baking dish. Sprinkle 1 1/2 cups cheddar cheese evenly on top.
- Bake uncovered for 25–30 minutes, until hot and bubbly.
- Remove from oven, sprinkle with remaining cheese, and bake for 5 more minutes until melted.
- Garnish with parsley before serving.
Notes
- Rotisserie chicken works perfectly for this recipe.
- Adjust spice by reducing or omitting cayenne pepper.
- Pairs well with garlic bread or a side salad.
- Prep Time: 15 mins
- Cook Time: 35 mins
- Category: Main Course
- Method: Baking
- Cuisine: Southern
Ingredients
(Tip: You can find the complete list of ingredients and their measurements in the recipe card below.)
Spaghetti – The pasta base, cooked until just al dente so it doesn’t overcook when baked.
Chicken breast or thighs – Cooked and shredded, providing hearty protein.
Cream of mushroom soup – Adds creamy texture and savory depth.
Cream of chicken soup – Enhances richness and ties the sauce together.
Chicken broth – Keeps the sauce smooth and adds flavor.
Onion and bell pepper – Diced and sautéed for aromatic flavor.
Rotel tomatoes with green chilies – Adds a tangy, slightly spicy kick that’s classic in Southern cooking.
Cheddar cheese – Melts into the casserole for creamy, gooey richness.
Velveeta cheese (optional) – For extra creaminess and that signature Southern casserole texture.
Garlic powder and paprika – Infuse flavor into the sauce.
Salt and black pepper – Balance and elevate the flavors.
Fresh parsley – A garnish for brightness and color before serving.
Directions
Preheat oven to 350°F (175°C) and lightly grease a 9×13-inch baking dish. Cook spaghetti until al dente, drain, and set aside.
In a large skillet, sauté onion and bell pepper in a bit of butter or olive oil until softened. Stir in cream of mushroom soup, cream of chicken soup, chicken broth, Rotel tomatoes, garlic powder, paprika, salt, and pepper. Mix until smooth and bubbling.
Add shredded chicken and cooked spaghetti to the skillet, tossing until well coated. Stir in half the cheddar cheese. Transfer the mixture into the prepared baking dish and top with the remaining cheddar cheese (and Velveeta if using).
Bake uncovered for 25–30 minutes, until the cheese is melted and bubbly. Garnish with fresh parsley before serving.
Servings and timing
This recipe makes about 6–8 servings. Preparation takes 20 minutes, and baking requires 30 minutes, for a total of around 50 minutes.
Storage/reheating
Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat in the oven at 350°F (175°C) until warmed through, or microwave in short intervals. For longer storage, freeze unbaked chicken spaghetti (without cheese topping) for up to 2 months, then thaw overnight and bake as directed.
Variations and Customizations
Spicy Southern style – Add extra jalapeños or cayenne pepper for more heat.
Veggie boost – Stir in mushrooms, spinach, or zucchini for added nutrition.
Creamier version – Use extra Velveeta cheese in the sauce for richness.
Bacon lovers – Mix in crispy bacon bits for a smoky flavor.
Low-carb option – Replace spaghetti with zucchini noodles or spaghetti squash.
Tex-Mex twist – Add taco seasoning and top with crushed tortilla chips.
Three-cheese bake – Mix cheddar, mozzarella, and Monterey Jack for a gooey, flavorful topping.
One-pot method – Cook the pasta directly in the sauce with extra broth, then finish with cheese.
FAQs
What makes Southern chicken spaghetti different from Italian spaghetti?
It’s baked in a creamy, cheesy sauce instead of tomato-based marinara.
Can I use rotisserie chicken?
Yes, it’s a time-saving option and works perfectly.
Can I make this ahead of time?
Yes, assemble the casserole and refrigerate for up to 24 hours before baking.
Can I freeze chicken spaghetti?
Yes, freeze unbaked for best results and bake fresh when needed.
What cheese works best?
Sharp cheddar is classic, but Velveeta adds extra creaminess.
Do I have to use Rotel?
It’s traditional, but you can use canned diced tomatoes with green chilies.
How do I keep the pasta from getting mushy?
Cook it al dente since it continues cooking in the oven.
Conclusion
Homemade Southern Chicken Spaghetti is a creamy, cheesy casserole that embodies Southern comfort cooking at its best. With its tender chicken, tangy tomatoes, and gooey cheese, it’s a crowd-pleasing dish that’s perfect for family dinners, potlucks, or make-ahead meals. Easy, versatile, and deeply satisfying, this recipe is sure to become a cherished favorite at your table.